Ergothioneine Improves Memory & Sleep in Older Adults
Cognitive decline is common in older people. A still little discussed nutrient found in mushrooms, ergothioneine, might help.
Ergothioneine is a vitamin-like amino acid found most abundantly in mushrooms. Evidence is mounting that, because of its antioxidant, inflammation regulating and detoxifying properties, ergothioneine may powerfully promote longevity. Studies show that ergothioneine levels are lower in elderly people with mild cognitive impairment.
North Americans may not get enough ergothioneine in their diet. When Americans add mushrooms to their diet, rates of premature death go down by 16%: 35% if you also reduce red meat.
You can increase ergothioneine by eating more mushrooms, especially shiitake, maitake, lion’s mane and oyster. You can also increase ergothioneine with supplements.
Several studies have shown that low levels of ergothioneine are associated with mild cognitive impairment, dementia, cerebral vascular disease and Parkinson’s. One study found that low levels of ergothioneine predict quicker cognitive decline. But few studies have looked at the effect of supplementing ergothioneine on cognition.
This new 16-week, double-blind, placebo-controlled study included 127 people between 55 and 79 years old with subjective memory complaints but no mild cognitive impairment or dementia.
It found that 25mg of ergothioneine significantly protected against subjective memory decline compared to placebo. This result is important both in itself and because subjective memory assessment is increasingly being recognized as an important marker of early cognitive decline and later decline.
The study also found that 25mg of ergothioneine significantly improved ease of falling asleep compared to the placebo group.
This important study provides preliminary promise for ergothioneine as a longevity nutrient that could improve memory.
Nutraceuticals. 2025;5(3):15.
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For much more on natural help for cognition, memory and sleep, see our book The Family Naturopathic Encyclopedia.
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