Could a Simple Omega-3 EFA Help PTSD?

Earlier observational studies have suggested that the omega-3 essential fatty acid eicosapentaenoic acid (EPA) could protect against posttraumatic stress disorder (PTSD). This randomized, controlled study set out to test that suggestion. . . .

110 people who had sustained severe physical injuries from accidents and who now suffered from non-severe PTSD were included in the study. They were given a daily dose of 1,470 mg DHA and 147 mg EPA or of placebo for 12 weeks. The severity of their PTSD improved significantly as levels of EPA went up. As the inflammatory arachidonic acid (AA) went up, PTSD severity got worse.

Observational studies have hinted that inflammatory markers are higher in people with PTSD. So EPA may be helping because it is anti-inflammatory, while AA may be hurting because it is inflammatory.

This study suggests the important possibility that EPA omega-3 fatty acids may help people suffering from PTSD.

Journal of Affective Disorders 2016;205:289-91

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