In this double-blind, placebo-controlled study, forty-two women who suffered at least three hot flashes a day were given either 300mg of St. John's wort or a placebo three times a day for three months. . . .  The St. John's wort group reduced their number of hot flashes by 2.3 compared to only a drop of one in the placebo group. Intensity scores went down by 3.8 points in the herb group compared to only 1.8 in the placebo group. Though these numbers are impressive, because of the study's design, they did not reach statistical significance. 50% of the St. John's wort group experienced a clinically significant improvement compared to only 22.7% of the placebo group, and the herb group had significant improvement in four out of five catagories of quality of life compared to the placebo group. Sleep problems--which are common during menopause--also significantly improved in the herb group compared to the placebo group.

  • Med Sci Monit 2009;16:307-14


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