It has long been suggested that N-Acetyl-cysteine (NAC) might be beneficial for COVID. What may be the first study has now been published to test this suggestion. And the answer is . . . .

Glutathione deficiency has been suggested as a key player in serious illness and death from COVID. One of the best ways to boost glutathione is to supplement NAC.

NAC helps clear mucous and is beneficial in lung conditions like bronchitis and asthma. It can improve lung function, reduce coughing and improve oxygen saturation. All of these well-known roles could be relevant to treating COVID. Also relevant to COVID is NAC’s ability to act as an antioxidant and anti-inflammatory and its role in preventing blood clots.

This Spanish study evaluated the benefit of NAC in people who were hospitalized with COVID and pneumonia. It compared patients who had 600mg of NAC every 8 hours added to their treatment with patients who did not add NAC to their treatment.

It was a tough test for NAC because the people in the NAC group were at higher risk of severe illness and death from COVID since they were, on average, 4.2 years older and had higher prevalence of high blood pressure, cholesterol problems, diabetes and COPD.

Despite the higher risk factors, patients treated with NAC had 44% lower rates of death from COVID.

This may be the first study to show that NAC increases survival in people hospitalized with COVID.

Sci Prog. 2022 Jan; 105(1): 00368504221074574

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