grape seed extract improves blood pressure and cholesterol

We typically eat the fruit and throw away the seed. But that little seed may be valuable for your heart. Emerging research is suggesting that grape seed extract may be important for cardiovascular health.

The past few years have seen the growth of research suggesting that the versatile and powerful antioxidant supplement grape seed extract may be useful for cardiovascular health.

A study published in 2019 showed that grape seed extract containing 400mg of proanthocyanidins significantly decreased systolic blood pressure in people with prehypertension. Measures of vascular function, including stiffness and elasticity, also significantly improved. A placebo brought about no such improvement. In nonsmokers, diastolic blood pressure also significantly improved (Nutrients 2019;11(12)).

This study built on earlier research on prehypertensive people that found that grape seed extract significantly lowered both systolic and diastolic blood pressure (J Pharm Nutr Sci 2012:155-9; Br J Nutr. 2016 Jan 28;115(2):226-38).

In 2021, a study found that 300mg of grape seed extract significantly increased the heart healthy HDL cholesterol while significantly lowering the heart harmful LDL cholesterol and triglycerides (Phytother Res 2021 Feb;35(2):987-995).

And now, there’s new evidence. The newest research is a systematic review and meta-analysis of 19 controlled studies of the long-term effect of grape seed extract. Supplementing grape seed extract significantly lowered diastolic blood pressure as well as heart rate. It did not detect an effect on systolic blood pressure or flow-mediated dilation. The researchers concluded that grape seed extract “may be beneficial for individuals with or at risk of cardiovascular disease because it may have hypotensive and HR-lowering properties (Pharmacol Res. 2022 Jan;175:105905).


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For much more on preventing and treating high blood pressure naturally, see our book The Family Naturopathic Encyclopedia.

For more on grape seed extract, see our book Healthy Herbs: Your Everyday Guide to Medicinal Herbs and Their Use.

For comprehensive help with blood pressure and heart health, make an appointment to see Linda Woolven nowLinda’s clinic is now open for virtual appointments.

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