palmitoylethanolamide (PEA) and luteolin help people who had COVID recover their sense of smell

One of the main symptoms of COVID is loss of the senses of smell or taste. About 30% of people who have had COVID continue to experience the loss as a long term consequence of the virus. A small study has now found that there may be a natural solution.

Recently, we talked about an in vitro study that suggested that a combination of Palmitoylethanolamide (PEA) and lipoic acid might help calm the cytokine storm of COVID.

Now another study has put PEA to the test against COVID. This time, it was an actual human study and the challenge was, not the cytokine storm, but the common loss of smell.

The loss of smell of COVID may be caused by inflammation in the olfactory bulb. As we saw in the previous study, PEA is a powerful anti-inflammatory. This study combined PEA with the flavonoid luteolin.

Twelve people who had had confirmed COVID and whose impaired sense of smell had persisted for more than 90 days after testing negative either underwent olfactory rehabilitation twice a day or just once a week while taking PEA and luteolin.

The people taking the PEA and luteolin had significantly greater improvement in olfactory threshold, discrimination, and identification scores. Olfactory threshold scores measure the lowest concentration of an odor that a person can smell. Olfactory discrimination measures the ability to distinguish between two different smells. Identification is the ability to detect an odor and match it to a word or be able to describe it. The longer the sense of smell had been affected, it seemed, the better the supplements worked.

If you’ve had COVID and are still missing full sense of smell, this small study suggests that the combination of PEA and luteolin may help you recover your sense of smell.


Eur Rev Med Pharmacol Sci 2021 06 ;25(11):4156-4162


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