adding rhodiola significantly improves antidepressant effect of sertraline (Zoloft)

This herb already has a host of benefits for your brain and mood. But if you are on antidepressants, you may also want to know about this herb. It may make you feel a lot better.

An exotic, but easy to get herb, known as Rhodiola rosea has been shown to have many benefits for mental health. We already know it helps stress, anxiety, anger, burnout and fatigue. Now we can add depression to the list.

The new 12 week study was double-blinded and included 100 people with mild-to-moderate depression. They were randomized into three groups. The first group received sertraline (Zoloft) with a placebo. The second received sertraline and 600mg of rhodiola. The third group took sertraline and 300mg of rhodiola.

Adding both doses of rhodiola was significantly better than taking sertraline alone: they led to significantly greater improvement on the Hamilton Depression Scale, the Beck Depression Inventory and the Clinical Global Impression Change. The improvement in the high dose rhodiola group was significantly greater than in the low dose group. The rhodiola group also had improvements in insomnia, emotional stability and physical complaints.

Interestingly, people who took rhodiola had fewer adverse events than people who took sertraline alone. So, rhodiola can improve depression and quality of life.

This is a potentially exciting new use of rhodiola.


J Affect Disord March 15, 2020;265:99–103


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